06:00 PM - 07:30 PM 
Strategy commission (closed session)

:

07:00 PM - 10:00 PM 
Welcome reception

07:45 PM - 08:15 PM 
Opening Keynote Lecture

Immune function in patients with CLL

08:15 PM - 10:00 PM 
Working Dinner

08:00 AM - 09:00 AM 
CLL-RT2 Investigator Meeting (closed session)

09:00 AM - 09:20 AM 
Check-in

09:20 AM - 09:30 AM 
Welcome

Young Investigator Meeting (YIM) : YIM Session I: Clinical & Translational Research

09:30 AM - 09:45 AM 
Selected YIM-Abstract #1

Ibrutinib lead-in followed by venetoclax plus ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia

09:45 AM - 10:00 AM 
Selected YIM-Abstract #2

Incidence of Richter transformation in patients with chronic lymphocytic leukemia (CLL): a cohort study evaluating different therapeutic eras

10:00 AM - 10:15 AM 
Selected YIM-Abstract #3

Prevalence and clinical impact of clonal hematopoiesis in chronic lymphocytic leukemia

10:15 AM - 10:30 AM 
Selected YIM-Abstract #4

Preclinical efficacy of the BCL2i venetoclax combined with MEKi cobimetinib or SYKi entospletinib in BTKi-refractory CLL patients harboring BTK mutations

10:30 AM - 10:45 AM 
Selected YIM-Abstract #5

Targeting NF-κB-inducing kinase (NIK) in chronic lymphocytic leukaemia

10:45 AM - 11:00 AM 
Selected YIM-Abstract #6

The Gene Expression Landscape of BTK Inhibitor Treatment in Chronic Lymphocytic Leukemia Exposed by Shallow Depth RNA Sequencing

11:00 AM - 11:30 AM 
Coffee & Tea

Young Investigator Meeting (YIM) : YIM Session II: Translational & Basic Research

11:30 AM - 11:45 AM 
Selected YIM-Abstract #7

TLR9 signaling is a potential tumor escape mechanism following B-cell receptor targeted treatments in subsets of

11:45 AM - 12:00 PM 
Selected YIM-Abstract #8

BH3 Profiling Identifies Anti-Apoptotic Dependencies and Therapeutic Vulnerabilities in Primary Richter Transformation (RT) Cells and in a Genetically-Engineered Murine Model of RT

12:00 PM - 12:15 PM 
Selected YIM-Abstract #9

LYN kinase activity and its regulator CSK are key players in CLL supporting macrophages

12:15 PM - 12:30 PM 
Selected YIM-Abstract #10

Impact of Germline and Somatic ATM Variants in Chronic Lymphocytic Leukemia (CLL): Clinical Implications and Response to PARP Inhibition

12:30 PM - 12:45 PM 
Selected YIM-Abstract #11

Role of G protein-coupled receptor kinase 2 (GRK2) in the localization and activation of leukemic cells

12:45 PM - 01:00 PM 
Selected YIM-Abstract #12

Rps15-S138F mutation results in translational errors underlying onset of chronic lymphocytic leukemia

01:00 PM - 01:45 PM 
Lunch

German CLL Study Group studies :

01:45 PM - 01:55 PM 
CLL 13 - Minimal Residual Disease: status and outcome

01:55 PM - 02:05 PM 
CLL12 | CLL13 | CLL14 - Genetic subgroups: different studies, same findings?

German CLL Study Group studies :

02:05 PM - 02:10 PM 
CLL ReVenG

02:10 PM - 02:15 PM 
CLL16

02:15 PM - 02:20 PM 
CLL17

02:20 PM - 02:30 PM 
Discussion

German CLL Study Group studies :

02:30 PM - 02:35 PM 
CLLRT1

02:35 PM - 02:40 PM 
CLLFrail

02:40 PM - 02:50 PM 
Discussion

German CLL Study Group studies :

02:50 PM - 02:55 PM 
CLL18

02:55 PM - 03:00 PM 
CLLRT2

03:00 PM - 03:05 PM 
Shall we address the tumor microenvironment?

03:05 PM - 03:10 PM 
Bendamustine debulking - yes or no?

03:10 PM - 03:20 PM 
Discussion

03:20 PM - 03:50 PM 
Coffee & Tea

03:50 PM - 04:05 PM 
Genomic Map of CLL

04:05 PM - 04:20 PM 
Richter Transformation

04:20 PM - 04:35 PM 
TP53 and beyond

04:35 PM - 04:50 PM 
Genetic and epigenetic evolution

Young Investigator Meeting (YIM) : YIM Session III: Guided Poster Walk with Coffee & Tea

04:50 PM - 05:00 PM 
Selected Abstract #13 (Poster)

Adaptation of chronic lymphocytic leukemia to ibrutinib is L mediated by epigenetic plasticity of residual disease and by-pass signaling via MAPK pathway

05:00 PM - 05:10 PM 
Selected Abstract #14 (Poster)

Combined therapy of endocytosis inhibitors and a novel glycoengineered anti-ROR1 antibody to enhance antibody-dependent cellular cytotoxicity (ADCC) against chronic lymphocytic leukemi

05:10 PM - 05:20 PM 
Selected Abstract #15 (Poster)

A Comparative Study of Different Macrophage Feeder Systems for the Support of Chronic Lymphocytic Leukemia Survival

05:20 PM - 05:30 PM 
Selected Abstract #16 (Poster)

CAR T cells generated from CLL patients are characterized by determinants of immune dysfunction that may be positively modulated by treatment with targeted agents

05:30 PM - 05:40 PM 
Selected Abstract #17 (Poster)

Venetoclax resistant cells are sensitive to anti-CD20 V monoclonal antibodies.

05:40 PM - 05:50 PM 
Selected Abstract #18 (Poster)

Utility of the international chronic lymphocytic leukemia prognostic index in front-line treatment with targeted drugs

Satellite Symposium : AbbVie

05:50 PM - 06:20 PM 
Time limited treatment regimens in CLL – Present or Future

Satellite Symposium : AstraZeneca

06:20 PM - 06:50 PM 
Pattern of Resistance in CLL and its Clinical Implications

06:50 PM - 07:40 PM 
Flying Dinner

Keynote Lecture :

07:40 PM - 07:50 PM 
Introduction

07:40 PM - 08:20 PM 
Keynote Lecture

08:20 PM - 10:00 PM 
Get together

08:00 AM - 09:00 AM 
CLL18 Kick-Off-Meeting (closed session)

09:00 AM - 09:15 AM 
Welcome

Session II : Treatment of CLL

09:15 AM - 09:30 AM 
Selecting a first-line treatment – what do we know, what do we need, what is standard?

09:30 AM - 09:45 AM 
Relapsed CLL – is it just second first-line?

09:45 AM - 10:00 AM 
Double Refractory (BTKi and BCL2i:) – what comes next?

Satellite Symposium : BeiGene

10:00 AM - 10:30 AM 
"Mental health in patients with CLL"

10:30 AM - 11:00 AM 
Coffee & Tea

Satellite Symposium : Janssen

11:00 AM - 11:30 AM 
"CLL therapy today and tomorrow"

Session III : Daily challenges in CLL management

11:30 AM - 11:45 AM 
Autoimmune conditions

11:45 AM - 12:00 PM 
Infections

12:00 PM - 12:15 PM 
Richter Transformation

12:15 PM - 12:30 PM 
YIM Awards

12:30 PM - 01:30 PM 
Lunch

Satellite Symposium : Lilly

01:30 PM - 02:00 PM 
"Latest CLL data – ready for clinical routine?"

Session IV : Perspectives

02:00 PM - 02:15 PM 
Novel targets

02:15 PM - 02:30 PM 
Cellular and bispecific therapies

02:30 PM - 02:45 PM 
Prognostic & predictive factors: future roles

02:45 PM - 03:00 PM 
Dream your study

03:00 PM - 03:15 PM 
Closing remarks

Day 1
04/18/2024
Day 2
04/19/2024
Day 3
04/20/2024